In our Science work, our mission is to support science and technology that will help make it possible to cure, prevent, or manage all diseases by the end of the century. We build open source software tools to accelerate science and generate more accurate and biologically important sources of data, fund scientific research worldwide to advance the frontiers of knowledge, and launched a family of institutes to do research that can’t be done in conventional environments.
To accomplish our mission, we need to develop a dynamic, integrated view of biological systems in health and disease. The Chan Zuckerberg Institute for Advanced Biological Imaging (CZ Imaging Institute) aims to push forward the development and application of new imaging technologies over the next 15 years to obtain deep insights into the architecture of complex biological systems at the molecular level. Researchers will collaboratively develop breakthrough biological imaging systems centered around grand challenges that push the boundaries of what we can see and measure.
As an extension of the Chan Zuckerberg Initiative’s Imaging program, the CZ Imaging Institute will create breakthrough technologies — hardware, software, biological probes, data, and platforms — that will be made available to the scientific community and adopted worldwide through a combination of direct access to the institute, open sharing of advances, and commercial partnerships.
The Chan Zuckerberg Imaging Institute is seeking an experienced Scientist, Sample Labeling , to help develop new genetically encoded labels to facilitate next generation correlative cryo EM tomography-fluorescence microscopy. The goal is to have a minimally perturbing genetically encoded tag on the protein of interest that under small molecule control can be linked to a cryo-EM and fluorescent microscopy visible object.
What You'll Do
Design and implement new constructs for genetically encoded correlative light microscopy-cryoEM tomography labels
Express, purify and validate the designs in vitro
Collaborate with researchers to assess utility of the label designs for on-going biological projects
Revise designs as required
Keep abreast of the latest developments in labeling and implement new ideas as appropriate
Write technical reports and publications to document new findings and techniques
