The OpenFlexure Microscope is an open-source microscope 3D printed in plastic, with versions suitable for hobbyists, researchers, and lab technicians. Currently used around the world as an accessible, customisable alternative to expensive and fixed commercial microscopes, the OpenFlexure Microscope began life as an academic prototype for holding a lens and sample in place. Here we discuss how the project has developed, with applications including malaria diagnosis, super-resolution imaging and remote fieldwork. The project has also expanded as a community, with an online forum, accessible software and an international network of users.